Periprocedural Anticoagulation Management in Orthopedic Patients: Overview and Description of a Program Utilizing Pharmacogenetics
نویسنده
چکیده
• Objective: To review current recommendations for periprocedural anticoagulation management strategies in orthopedic patients and to describe a program utilizing pharmacogenetics in warfarin management of orthopedic surgical patients. • Methods: Review of the literature and descriptive
منابع مشابه
How To Manage Oral Anticoagulation Periprocedurally During Ablations And Device Implantations.
More than 150, 000 patients undergo ablation for atrial fibrillation (AF) each year.Current guidelines recommend oral anticoagulation in all patients undergoing AF ablation. A large number of patients undergoing cardiac implantable electronic devices (CIEDs) are on long-term oral anticoagulation. These patients are at increased risk for thromboembolism with interruption of oral anticoagulation....
متن کاملPeriprocedural bridging management of anticoagulation.
More than 2.5 million Americans are chronically anticoagulated for indications including venous thromboembolism (VTE), mechanical heart valve(s), or atrial fibrillation (AF).1 Each year, 10% of these patients require temporary interruption of anticoagulation for an invasive procedure. Defining the most appropriate management strategy for these patients requires an assessment of the periprocedur...
متن کاملAnticoagulation Strategies for the Orthopaedic Surgeon: Reversal and Timelines
Article Highlights: 1) This article provides a full anticoagulant reference for the practicing orthopaedic surgeon which can be used in any clinical scenario, whether urgent or elective surgical intervention is required 2) A comprehensive list of anticoagulant reversal agents and drugs with short half-lives (for bridging) are described with the intention to provide the data needed t...
متن کاملOutcomes and total costs of outpatient vs. inpatient peri-procedural anticoagulation management of mechanical prosthetic heart valve patients.
BACKGROUND/OBJECTIVES The most cost-effective periprocedural management of patients with mechanical heart valves (MHV) is uncertain. The objective was to compare the effectiveness, safety and costs for inpatient intravenous unfractionated heparin (IVUH) vs. outpatient low molecular weight heparin (LMWH) "bridging" as periprocedural anticoagulation management for MHV patients. METHODS In a cas...
متن کاملThe potential clinical and economic outcomes of pharmacogenetics-oriented management of warfarin therapy - a decision analysis.
Variant cytochrome P450 (CYP) 2C9 genotypes are associated with low maintenance dose requirement of warfarin therapy and increased risk of major bleeding events. The objective of the present study was to evaluate the potential clinical and economic outcomes of using CYP2C9 genotype data to guide the management of anticoagulation therapy and to identify influential factors affecting the cost-eff...
متن کامل